(S)-(-)-Bay-K-8644 是 L 型 Ca2+ 通道的激动剂，可激活 Ba2+ 电流，其EC50 为 32 nM。

(S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel and activates Ba2+ currents with an EC50 of 32 nM.

The Ca2+ channel activity is enhanced by 3–30 μM (S)-(-)-Bay-K-8644 an agonist of L-type Ca2+ channels [1]. FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by (S)-(-)-Bay-K-8644 (EC50: 14 nM). (S)-(-)-Bay-K-8644 (100 nM) increases whole-cell Ca2+ currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176 [2]. (S)-(-)-Bay-K-8644 can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on IBa in gastric myocytes of the guinea pig antrum [3].

98625-26-4

C16H15F3N2O4

356.3

(S)-(-)-Bay K 8644;(S)-(-)-Bay-K-8644

H2O:< 0.1 mg/mL (insoluble) ,ultrasonic warming heat to 60°C
DMSO:120 mg/mL (336.79 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years