Coenzyme A 是所有活细胞中必需的辅助因子，由泛酸，三磷酸腺苷和半胱氨酸合成的。Coenzyme A 与过氧化物酶 5 共价结合导致其过氧化物酶活性完全抑制，通过 DTT 还原能够逆转。Coenzyme A 及其硫酯衍生物是主要分解代谢，合成代谢途径和基因表达调控的关键参与者。

Coenzyme A is an obligatory cofactor in all living cells synthesized from pantothenate (Vitamin B5), adenosine triphosphate (ATP), and cysteine.

Covalent binding of Coenzyme A to Peroxiredoxin 5 (Prdx5) results in complete inhibition of its peroxidase activity, which is reversed by reduction with DTT. Many human pathologies, including cancer, diabetes, and neurodegeneration, have been associated with abnormal biosynthesis and homeostasis of CoA and its derivatives.

85-61-0

C21H36N7O16P3S

767.53

Coenzyme A

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