Vps34-IN-1 是一种有效且高度选择性的 Vps34 抑制剂，可调节自噬，来自从专利WO2012085815A1，化合物实例16a，IC50为4nM。

Vps34-IN1 is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM invitro, which does not significantly inhibit the isoforms of class I as well as class II PI3Ks.

Administration of VPS34-IN1 to cells induces a rapid dose-dependent dispersal of a specific PtdIns(3)P-binding probe from endosome membranes, within 1min, without affecting the ability of class I PI3K to regulate Akt. It can also induce a rapid ~50-60% loss of SGK3 phosphorylation within 1min. VPS34-IN1 has no inhibition to the SGK2 isoform that does not possess a PtdIns(3)P-binding PX domain[1].

1383716-33-3

C21H24ClN7O

425.92

VPS34-IN1;Vps34-IN-1

H2O:<1 mgml
Ethanol:79 mg/mL (185.5 mM)
DMSO:79 mg/mL (185.5 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years