RTC-5 (TRC-382) 是一种具有抗癌效力的优化吩噻嗪。RTC-5 显示针对 EGFR 驱动的癌症的异种移植模型的功效，其效果归因于 PI3K-Akt 和 Ras-ERK 信号传导的负调节。
产品描述
RTC-5 (TRC-382) is an optimized phenothiazine with anti-cancer potency. RTC-5 demonstrates efficacy against a xenograft model of an EGFR driven cancer, its effects is attributed to concomitant negative regulation of PI3K-AKT and RAS-ERK signaling.
体外活性
H1650 lung adenocarcinoma cell growth inhibited by RTC-5 (0-40 μM; 48 hours) (GI50 of 12.6μM). RTC-5 (20-40 μM; 24 hours) negatively regulates PI3K-AKT and RAS-ERK pathways by decreasing phospho-AKT and phospho-ERK levels expression[1].
Cas No.
1423077-49-9
分子式
C24H22ClF3N2O3S
分子量
510.96
别名
TRC-382;RTC-5
储存和溶解度
DMSO:13.5mg/mL (26.4mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
