JQEZ5 是一种选择性EZH2赖氨酸甲基转移酶抑制剂，具有抗肿瘤作用。它以 SAM 竞争性方式抑制PRC2的酶功能，IC50为 80 nM。
产品描述
JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM).
体内活性
JQEZ5 inhibits colony formation of primary human CD34+ chronic myelogenous leukemia (CML) stem/progenitor cells but not non-cancerous human CD34+ hematopoietic stem/progenitor cells when used at concentrations ranging from 0.5 to 5 μM
Cas No.
1913252-04-6
分子式
C30H38N8O2
分子量
542.688
别名
JQEZ5
储存和溶解度
DMSO:25 mg/mL (46.07 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
