BobCAT339 hydrochloride 是一种有效的、选择性的基于胞嘧啶的TET酶抑制剂，抑制TET1和TET2的IC50值分别为 33 μM 和 73 μM。BobCAT339 hydrochloride 可用于表观遗传学领域研究，并且可作为靶向 DNA 甲基化和基因转录新疗法的起点。

Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme, with the IC 50 s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription [1].

Bobcat339 (10 μM; 24 hours) significantly reduces global 5hmC levels by inhibiting TET enzyme function in HT-22 cells [1].

2436747-44-1

C16H13Cl2N3O

334.2

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years