CPTH2 is an inhibitor of the HAT activity of Gcn5.

In vitro: The previous study identified a novel molecule named CPTH2, which was selected based on its inhibitory effect on the growth of a gcn5Delta strain. This study indicated a specific chemical-genetic interaction between CPTH2 and HAT Gcn5p, suggesting that CPTH2 could inhibit the dependent functional network of Gcn5p. In addition, CPTH2 was found to be able to inhibit an in-vitro HAT reaction, which could be reversed by increasing the concentration of histone H3 [1].

In vivo: CPTH2 could decrease the acetylation of bulk histone H3 at the specific H3-AcK14 site [1].

2108899-91-6

C14H15Cl2N3S

328.26

CPTH2 (hydrochloride);CPTH2 (hydrochloride) (357649-93-5 free base)

DMSO:16mg/ml
Ethanol:≤5mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years