FATP1-IN-1 (compound 5k) 是一种脂肪酸转运蛋白 1 (FATP1) 抑制剂。FATP1-IN-1 抑制重组人或小鼠 FATP1 acyl-CoA 合成酶活性，IC50 值分别为 0.046 μM和 0.60 μM。

FATP1-IN-1 is a fatty acid transport protein 1 (FATP1) inhibitor. FATP1-IN-1 is an inhibition of recombinant human or mouse acyl-CoA synthetase activity of FATP1, with the IC 50 values of 0.046 μM or 0.60 μM, respectively.

FATP1-IN-1 (p.o.; 10 mg/kg) treatment shows the C max , AUC and T max were 5.5 μg/mL, 36 μg h/mL and 0.33 hours, respectively, and exceeds the mouse IC 50 value of 0.22 μM without considering plasma protein binding. Animal Model: Mouse plasma [1] Dosage: 10 mg/kg Administration: P.o. Result: The C max , AUC and T max were 5.5 μg/mL, 36 μg h/mL and 0.33 hours, respectively.

1431945-95-7

C18H22FN5OS

375.47

FATP1-IN-1;FATP1-IN-1

DMSO:56.2 mg/mL (149.8 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years