Ned-K 是烟酸腺嘌呤二核苷酸磷酸 (NAADP) 拮抗剂。Ned-K 可有效抑制心肌缺血和再灌注 (sIR) 诱导的钙振荡。

Ned-K is a nicotinic acid adenine dinucleotide phosphate ( NAADP ) antagonist. Ned-K is effective at dampening simulated ischaemia and reperfusion (sIR)-induced Ca 2+ oscillations in cardiomyocytes [1].

Ned-K suppresses Ca 2+ oscillations and dramatically protects cardiomyocytes from cell death in vitro after ischaemia and reoxygenation, preventing opening of the mitochondrial permeability transition pore. Ned-K (10 μM) almost completely eliminates [Ca 2+ ] c oscillations, and Ned-K (0.1 μM) is effective at suppressing [Ca 2+ ] c levels [1]. Cell Viability Assay [1] Cell Line: Dead primary adult cardiomyocytes Concentration: 0.1 and 10 μM Incubation Time: Result: Treatment with 0.1 μM caused a slight decrease in cardiomyocyte death (34±6%). Treatment with 10 μM at reoxygenation significantly decreased cell death after sIR to 16±1%.

Injection of Ned-K causes a significant reduction in infarct size in mice. Ned-K (administered i.v. to mice 5 min before reperfusion) significantly decreases myocardial infarct size relative to area at risk [1].

2250019-90-8

C31H31N5O3

521.61

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years