hCAIX/XII-IN-1 是一种有效的CAIX/XII抑制剂，KI值分别为 0.48 μM 和 0.83 μM。hCAIX/XII-IN-1 显示出体外抗增殖活性。hCAIX/XII-IN-1 诱导 MCF-7 细胞凋亡Apoptosis。

hCAIX/XII-IN-1 is a potent CAIX/XII inhibitor with the K I values of 0.48 μM and 0.83 μM for CAIX and CAXII, respectively. hCAIX/XII-IN-1 shows antiproliferative activity in vitro. hCAIX/XII-IN-1 induces apoptosis in MCF-7 cells [1].

hCAIX/XII-IN-1 (compound 11a) (3.125, 6.25, 12.5, 25, 50 μM, 48 h) shows antiproliferative activity with an IC 50 value of 0.48 μM in MCF-7 cells [1]. hCAIX/XII-IN-1 (0.48 μM; 24 h) increases the cell populations of Sub-G1 phase [1]. hCAIX/XII-IN-1 (0.48 μM) induces apoptosis in MCF-7 cells [1]. Cell Proliferation Assay [1] Cell Line: MCF-7 cells Concentration: 3.125, 6.25, 12.5, 25, 50 μM Incubation Time: 48 h Result: Showed antiproliferative activity with an IC 50 value of 0.48 μM in MCF-7 cells. Cell Cycle Analysis [1] Cell Line: MCF-7 cells Concentration: 0.48 μM Incubation Time: 24 h Result: Significantly increased the cell populations of Sub-G1 phase. Apoptosis Analysis [1] Cell Line: MCF-7 cells Concentration: 0.48 μM Incubation Time: Result: Induced apoptosis in MCF-7 cells.

C19H11NO5S2

397.42

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years