SGK1-IN-1 is a highly active and selective SGK-1 inhibitor(IC50 of 1 nM).

SGK1-IN-1 (14n) shows an acceptable SGK isoform selectivity with a good activity on hSGK2 and a moderate activity on the hSGK3(IC50s of 1, 41 nM at 10 μM and 50 μM ATP concentration, respectively). SGK1-IN-1 also displays cellular activity in a SGK1-dependent phosphorylation of GSK3β assay in U2OS cells with activities of 0.69 μM[2].

1279829-87-6

C17H12ClFN6O2S

418.83

SGK1-IN-1

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years