ZK824859 hydrochloride is an oral available and selective inhibitor of urokinase plasminogen activator (uPA)(IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively).

ZK824859 is 5 fold less potent and has lost selectivity in mouse: uPA with IC50 of 410?nM; tPA with IC50 of 910?nM; plasmin with IC50 of 1600?nM compared to human IC50 of 79?nM, 1580?nM and 1330?nM respectively.

T13409L

C23H23ClF2N2O4

464.89

ZK824859 hydrochloride;ZK824859 hydrochloride (2271122-53-1 free base)

DMSO:125 mg/mL (268.88 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years