PI3K-IN-29 是一种有效的PI3K抑制剂。PI3K-IN-29 对 U87MG、HeLa 和 HL60 细胞具有较好的抑制作用，IC50值分别为 0.264、2.04 和 1.14 μM。PI3K-IN-29 通过抑制PI3K催化的Akt的磷酸化来抑制PI3K/Akt通路。
产品描述
PI3K-IN-29 is a potent PI3K inhibitor. PI3K-IN-29 displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC 50 values of 0.264, 2.04 and 1.14 μM, respectively. PI3K-IN-29 inhibits PI3K/Akt pathway by inhibiting phosphorylation of Akt that is catalyzed by PI3K [1].
体外活性
PI3K-IN-29 (compound 25) (72 h) displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC 50 values of 0.264, 2.04 and 1.14 μM, respectively [1]. PI3K-IN-29 (U87MG cells; 1, 5 μM; 1 h) inhibits PI3K/Akt pathway by inhibiting phosphorylation of Akt that is catalyzed by PI3K [1]. Cell Proliferation Assay [1] Cell Line: U87MG, HeLa, HepG2, A549, HL60, MCF7 cells Concentration: Incubation Time: 72 h Result: Displayed good inhibition potencies against U87MG, HeLa and HL60 cells with IC 50 values of 0.264, 2.04 and 1.14 μM, respectively. Western Blot Analysis [1] Cell Line: U87MG cells Concentration: 1, 5 μM Incubation Time: 1 h Result: Inhibited PI3K/Akt pathway by inhibiting phosphorylation of Akt that was catalyzed by PI3K.
分子式
C27H22ClN7O3S
分子量
560.03
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
