MRT68921 dihydrochloride 有效抑制ULK1和ULK2，IC50值分别为 2.9 nM和 1.1 nM。

MRT68921 dihydrochloride is a potent ULK1 and ULK2 inhibitor (IC50 of 2.9 nM and 1.1 nM, respectively).

MRT68921 inhibits ULK1 and ULK2 in vitro and block autophagy in cells.?MRT68921 is the most potent inhibitor of both ULK1 and ULK2, with greater than a 15-fold reduction in the IC50 for ULK1 (2.9 nm) and greater than a 30-fold reduction for ULK2 (1.1 nm).?Autophagy-inhibiting capacity of the compounds is specifically through ULK1.?ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation[1]

2080306-21-2

C25H36Cl2N6O

507.5

MRT68921 dihydrochloride

DMSO:2 mg/mL (3.94 mM),Need ultrasonic
H2O:33.33 mg/mL (65.67 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years