Paprotrain是可渗透细胞的Kinesin MKLP-2的抑制剂，抑制 MKLP-2 的 ATPase 活性，IC50值为 1.35 μM，Ki值为 3.36 μM。它对DYRK1A有中等的抑制作用，IC50值为 5.5 μM。
产品描述
Paprotrain inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM.
体外活性
Paprotrain-treated porcine oocytes suffer failure of nuclear maturation.?The number of oocytes arrested at early MI stage increase in a dose-dependent manner after KIF20A activity inhibition, while the percentage of oocytes that reach ATI and MII stages decrease after treatment[3].
Cas No.
57046-73-8
分子式
C16H11N3
分子量
245.28
别名
(alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile;Paprotrain
储存和溶解度
DMSO:100 mg/mL (407.70 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
