Ezutromid 是一种具有口服活性的、首创的苯并恶唑utrophin调节剂，EC50=0.91 μM。它抑制人肝微粒体 CYP1A2 酶活性，IC50=5.4 μM。它可用于 Duchenne 型肌营养不良症 (DMD) 的研究。
产品描述
Ezutromid is a translation modulator of Small utrophin (EC50: 0.4 uM). Ezutromid is an orally bioavailable small molecule that transcriptionally upregulates the utrophin gene, increasing both utrophin mRNA and protein. Through this action, Ezutromid increases muscle function in dystrophin-deficient MDX mice, a mouse model of muscular dystrophy.
Cas No.
945531-77-1
分子式
C19H15NO3S
分子量
337.39
别名
SMT C1100;依珠曲米;VOX-C1100;BMN 195;Ezutromid
储存和溶解度
H2O:<1 mgml
DMSO:10 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
