Lamotrigine hydrate 是一种有效的，具有口服活性的抗惊厥或抗癫痫试剂 (anticonvulsant agent)。Lamotrigine hydrate 选择性地阻断电压门控钠离子通道 (Na+channels)，稳定突触前神经元膜，抑制谷氨酸释放。Lamotrigine hydrate 可用于癫痫、局灶性癫痫等的研究。

Lamotrigine hydrate is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine hydrate selectively blocks voltage-gated Na + channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine hydrate can be used for the research of epilepsy, focal seizure, et al [1] [2].

Lamotrigine hydrate inhibits Veratrine evoked release of glutamate and aspartate with ED 50 values of 21 μM for both amino acids, but Lamotrigine hydrate is less potent in the inhibition of GABA release (ED 50 =44 μM. At concentrations up to 300 μM, LTG has no effect on patassium-evoked amino acid [1]. Lamotrigine hydrate is some five times less potent in the inhibition of Veratrine-evoked [ 3 H]acetylcholine release (ED 50 =100 μM) than in glutamate or aspartate release [1].

Lamotrigine hydrate (IP, 30 min before pentylenetetrazol; 10 mg/kg, 15 mg/kg or 20 mg/kg) decreases the seizure intensity at the higher doses, it increases the latency to the first pentylenetetrazol-induced seizure in all studied doses compared with the controls [2].

375347-20-9

C9H9Cl2N5O

274.11

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years