Smo-IN-3 (compound 12a) 是一种有效的Smoothened (Smo)抑制剂，对 hedgehog (Hh) 信号通路的IC50为 34.09 nM。Smo-IN-3 对人髓母细胞瘤细胞系 Daoy 有抗增殖作用。具有抗癌活性。

SMO-IN-3 (compound 12a) is a potent smoothened (SMO) inhibitor with an IC 50 value of 34.09 nM for hedgehog (Hh) signaling pathway. SMO-IN-3 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity [1].

SMO-IN-3 (compound 12a) has antiproliferative activity against human medulloblastoma cell line Daoy with an IC 50 of 0.48 μM [1].

2376914-71-3

C27H25F4N3O2

499.5

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years