Claficapavir (A1752) 是一种特异的核衣壳蛋白 (nucleocapsid protein) 抑制剂，IC50约为1μM。Claficapavir 与 HIV-1 NC(Kd=20 nM) 强烈结合，从而抑制 NC 的伴侣特性，并导致对 HIV-1 具有良好的抗病毒活性。

Claficapavir (A1752) is a specific nucleocapsid protein (NC) inhibitor with an IC 50 around 1 μM. Claficapavir strongly binds the HIV-1 NC (K d =20 nM) thereby inhibiting the chaperone properties of NC and leading to good antiviral activity against the HIV-1 [1].

Claficapavir binds directly to HIV-1 NC, thereby inhibiting specific chaperone functions of NC including Psi RNA dimerization and complementary trans-activation response element (cTAR) DNA destabilization, and it also disrupts the proper Gag processing [1].

2055732-24-4

C17H12ClNO4S2

393.86

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years