CROSstide TFA(171783-05-4 free base) 是糖原合酶激酶 α/β 融合蛋白序列的肽类似物，是 Akt 的底物。

Crosstide is a peptide analog of glycogen synthase kinase α/β fusion protein sequence which is a substrate for Akt.

16HBE14o? cells exposed to RV39 demonstrate a crosstide kinase activity in vitro. Serine phosphorylation of crosstide is confirmed by immunoblotting, and phosphorylation is blocked by PP2 but not by PP3[1]. The wildtype GST-AKT2 shows significant phosphoryl transferase activity towards crosstide, reaching an initial velocity of 16 pmol phosphate/min/μg enzyme. The mutant GST-AKT2T/E,S/D displayed an initial velocity of 85 pmol phosphate/min/μg kinase for phosphorylation of Crosstide, corresponding to a 5-fold increase compared to the wildtype enzyme[2].

TP1370L

C50H78F3N17O19

1278.25

Crosstide TFA(171783-05-4 free base)

H2O:50 mg/mL (42.95 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years