(4S,5R,6R)-5-乙酰氨基-4-胍基-6-((1R,2R)-2,3-二羟基-1-甲氧基丙基)-5,6-二氢-4H-吡喃-2-甲酸
R 125489
Laninamivir 是一种流感神经氨酸酶抑制剂，对流感病毒 H12N5 NA (N5)，pH1N1 N1 NA (p09N1) 和 A/RI/5+/1957 H2N2 N2 (p57N2) 的IC50值分别为 0.90 nM、1.83 nM 和 3.12 nM。
产品描述
Laninamivir is an effective inhibitor of influenza neuraminidase (NA) (IC50s: 0.90 nM, 1.83 nM, and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively).
体外活性
Laninamivir is effective against p57N2, p09N1, and N5 with a similar binding mode to Zanamivir. Laninamivir inhibits efficiently common oseltamivir-resistant viruses, including those with the ubiquitous His274Tyr substitution [1].
Cas No.
203120-17-6
分子式
C13H22N4O7
分子量
346.34
别名
(4S,5R,6R)-5-乙酰氨基-4-胍基-6-((1R,2R)-2,3-二羟基-1-甲氧基丙基)-5,6-二氢-4H-吡喃-2-甲酸;R 125489;Laninamivir
储存和溶解度
DMSO:Insoluble
H2O:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
