Fumagillin由烟曲霉菌中提取的一种抗菌药，有抗阿米巴活性。它通过抑制HIV-1 viral protein R活性来抑制HIV‐1感染。

Fumagillin is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis.

Fumagillin selectively inhibits the growth of a Δmap1 strain but not a wild-type or a Δmap2 S. cerevisiae strain missing MetAP-2. [1] In budding yeast cells, as a potent inhibitor of angiogenesis, Fumagillin not only reverses the growth inhibitory activity of Vpr, but also inhibits Vpr-dependent viral gene expression upon the infection of human macrophages. [3] Though the toxicity of fumagillin has limited its use for human applications, the analogues using structure-activity relationships relating to its angiogenesis properties may be further explored in the treatment of angiogenesis-dependent diseases. [4]

In DEN-treated rats, fumagillin (30 mg/kg, i.p.) inhibits both progression of HCC in the liver itself and systemic metastasis. [2]

23110-15-8

C26H34O7

458.551

烟曲霉素;NSC9168;Amebacilin;Fumagillin

DMSO:200.6 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years