As-358 对埃博拉病毒 (Ebola virus) 和马尔堡病毒 (Marburg virus) 具有抑制活性，IC50分别为 47.5 μM 和 3.7 μM。
产品描述
As-358 has inhibitory effects against Ebola virus and Marburg virus, with IC 50 s of 47.5 μM and 3.7 μM [1].
体外活性
As-358 (compound 3b) (0-500 μM; 10 days) exhibits inhibitory activities against EBOV and MARV [1]. As-358 (0-100 μM; 48 hours) can inhibit WT-EboV-GP and mutant D522A-EboV-GP, with IC 50 s of 1.7 and 2.2 μM, respectively [1]. Cell Proliferation Assay Cell Line: Vero (infected with EBOV and MARV) [1] Concentration: 0-500 μM Incubation Time: 10 days Result: Exhibited inhibitory activities against EBOV and MARV, with IC 50 s of 47.5 ± 8.2 μM and 3.7 ± 1.7 μM, SI values of 9 and 118, respectively.
Cas No.
2222042-47-7
分子式
C18H31NO2
分子量
293.44
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
