L-873724 inhibits bone resorption. L-873724 is an effective, selective, and reversible non-basic cathepsin K inhibitor (IC50s: 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively). L-873724 also shows an IC50 of 0.5 nM for rabbit cathepsin K.

L-873724 also displays IC50s of 95, 1221, and 4807 nM for Ramos cathepsin S, Hep G2 cathepsin L, Hep G2 cathepsin B[1].

In the rhesus monkey bone resorption model, L-873724 is orally bioavailable, non-lysosomotropic, and efficacious[1].

603139-12-4

C23H26F3N3O3S

481.53

L-873724

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years