UNC4203 是有效的、具有口服活性的、高度选择性的MERTK抑制剂，其对 MERTK、AXL、TYRO3 和 FLT3 的IC50值分别为 1.2 nM、140 nM、42 nM 和 90 nM。
产品描述
UNC4203 is a potent, orally available and highly selective MERTK inhibitor, with IC 50 s of 1.2 nM, 140 nM, 42 nM and 90 nM for MERTK, AXL, TYRO3 and FLT3, respectively [1].
体内活性
Mice are treated with UNC4203 (compound 24) at a dose of 10 mg/kg administered via oral (po) or iv routes. Under the condition, UNC4203 (compound 24) has 58% oral bioavailability with a 7.8 h half-life, 1.7 L/kg volume of distribution, and 36 mL/min/kg clearance [1].
Cas No.
1818234-19-3
分子式
C30H44N6O
分子量
504.71
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
