Mirk-IN-1 is an effective inhibitor of Dyrk1B(Mirk kianse) and Dyrk1A (IC50: 68±48 nM and 22±8 nM respectively).

Dyrk inhibitor Mirk-IN-1 had an EC50 of 1.9 ±0.2 mmol/L on SW620 cells. Mirk-IN-1 inhibited the activities of DYRK1A, ABL, FLT3, and MARK1 by 88%, 64%, 56%, and 73%, respectively, at a much higher concentration of 10 mmol/L in a kinase assay [1]. Mirk-IN-1 was able to block tumour cells from undergoing reversible arrest in a quiescent G0 state and enable some cells to exit quiescence [2].

1386979-55-0

C23H17Cl2N5O4

498.32

Dyrk1B/A-IN-1;Mirk-IN-1

DMSO:5 mg/mL (10.03 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years