Estradiol Cypionate(Depoestradiol)

Molecular Weight (MW)	396.56
Formula	C26H36O3
CAS No.	313-06-4
Storage	-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: 79 mg/mL (199.2 mM)
Water: <1 mg/mL
Ethanol: 55 mg/mL (138.7 mM)
Other info	Chemical Name: Cyclopentanepropionic acid, 3-hydroxyestra-1,3,5(10)-trien-17beta-yl ester InChi Key: UOACKFBJUYNSLK-XRKIENNPSA-N InChi Code: InChI=1S/C26H36O3/c1-26-15-14-21-20-10-8-19(27)16-18(20)7-9-22(21)23(26)11-12-24(26)29-25(28)13-6-17-4-2-3-5-17/h8,10,16-17,21-24,27H,2-7,9,11-15H2,1H3/t21-,22-,23+,24+,26+/m1/s1 SMILES Code: O=C(O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=C(C=CC(O)=C4)[C@@]3([H])CC[C@]12C)CCC5CCCC5
Synonyms	Estradiol cypionate; β-Estradiol 17-cypionate

Molecular Weight (MW)

396.56

Formula

C26H36O3

CAS No.

313-06-4

Storage

-20℃ for 3 years in powder form

-80℃ for 2 years in solvent

Solubility (In vitro)

DMSO: 79 mg/mL (199.2 mM)

Water: <1 mg/mL

Ethanol: 55 mg/mL (138.7 mM)

Other info

Chemical Name: Cyclopentanepropionic acid, 3-hydroxyestra-1,3,5(10)-trien-17beta-yl ester

InChi Key: UOACKFBJUYNSLK-XRKIENNPSA-N

InChi Code: InChI=1S/C26H36O3/c1-26-15-14-21-20-10-8-19(27)16-18(20)7-9-22(21)23(26)11-12-24(26)29-25(28)13-6-17-4-2-3-5-17/h8,10,16-17,21-24,27H,2-7,9,11-15H2,1H3/t21-,22-,23+,24+,26+/m1/s1

SMILES Code: O=C(O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=C(C=CC(O)=C4)[C@@]3([H])CC[C@]12C)CCC5CCCC5

Synonyms

Estradiol cypionate; β-Estradiol 17-cypionate

In Vitro	In vitro activity: Estradiol cypionate is a synthetic ester of the natural estrogen, estradiol. Compared to other commonly used estradiol esters, via the intramuscular route, estradiol cypionate is found to have the longest duration of action with a duration of ~11 days, while estradiol benzoate and estradiol valerate are found to last for 4-5 days and 7-8 days, respectively. Estradiol cypionate has several indications for use in bovine medicine. These include treatment of anestrus in the absence of follicular cysts, persistent corpus luteum, pyometra, and retained placenta. Potentially, ECP may benefit high-risk postpartum cows by stimulating uterine contractions either directly or through maintenance of oxytocin receptor sites in the uterus, bringing more WBCs to the site of infection by increasing blood flow to the uterus, enhancing uterine immune function by increasing phagocytosis of bacteria or movement of IgA and IgG into the uterine lumen, or promoting uterine drainage by delaying closure of the cervix.
In Vivo
Animal model
Formulation & Dosage
References	Contraception. 1980 Apr;21(4):415-24; J Am Vet Med Assoc. 2003 Sep 15;223(6):846-51.

In Vitro

In vitro activity: Estradiol cypionate is a synthetic ester of the natural estrogen, estradiol. Compared to other commonly used estradiol esters, via the intramuscular route, estradiol cypionate is found to have the longest duration of action with a duration of ~11 days, while estradiol benzoate and estradiol valerate are found to last for 4-5 days and 7-8 days, respectively. Estradiol cypionate has several indications for use in bovine medicine. These include treatment of anestrus in the absence of follicular cysts, persistent corpus luteum, pyometra, and retained placenta. Potentially, ECP may benefit high-risk postpartum cows by stimulating uterine contractions either directly or through maintenance of oxytocin receptor sites in the uterus, bringing more WBCs to the site of infection by increasing blood flow to the uterus, enhancing uterine immune function by increasing phagocytosis of bacteria or movement of IgA and IgG into the uterine lumen, or promoting uterine drainage by delaying closure of the cervix.

In Vivo

Animal model

Formulation & Dosage

References

Contraception. 1980 Apr;21(4):415-24; J Am Vet Med Assoc. 2003 Sep 15;223(6):846-51.

CAS NO:	313-06-4
规格:	≥98%

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