1-Oleoyl lysophosphatidic acid is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of phospholipase D (PLD) or through a two step process involving liberation of diacylglycerol (DAG) by phospholipase C (PLC) followed by phosphorylation of DAG by diglycerol kinase.[1] Hydrolysis of the fatty acid at the sn-2 position by phospholipase A2 (PLA2) yields bioactive LPA. LPA binds to one of five different G protein linked receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility.[2],[1] 1-Oleoyl lysophosphatidic acid is the most potent of the LPA analogs for calcium mobilization in A431 cells and for growth stimulation of a variety of cell lines.[3],[4]

65528-98-5

C21H41O7P

436.52

1-Oleoyl Lysophosphatidic Acid;Oleoyl-sn-3-Glycerophosphate;1-Oleoyl LPA;1-Oleoyl Lysophosphatidic Acid

Ethanol:25 mg/mL
PBS (pH 7.2):3 mg/mL
DMF:2 mg/mL
DMSO:2.5 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years