产品描述
Urocortin, rat TFA is a neuropeptide and a potent endogenous CRFR agonist (Kis: 0.97 nM, 1.5 nM, and 13 nM for mouse CRF2β, rat CRF2α, and human CRF1).
体外活性
In stably transfected Chinese hamster ovary cells, Urocortin, rat induces cAMP generation with EC50 of 0.15 nM, 0.063 nM, and 0.087 nM for human CRF1, rat CRF2α, and mouse CRF2β, respectively [2].
体内活性
Urocortin, rat (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such an effect also observed in mice after 1 μg of Urocortin, rat (i.c.v.). It has the potential of inducing anxiogenic behavior [3].
Cas No.
TP2159
分子式
C208H339N62F3O66
分子量
4821.28
别名
Urocortin (Rattus norvegicus) (TFA);Rat urocortin TFA;Urocortin, rat TFA;Urocortin, rat TFA (171543-83-2 free base)
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years