20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing degranulation of PMNL, but actually inhibits LTB4-induced degranulation of human neutrophils (Ki = 13.3 nM). However, 20-hydroxy LTB4 is as active as LTB4 in contracting parenchymal strips from guinea pig lung. 20-hydroxy LTB4 retains considerable ligand binding affinity at the BLT2 receptor, but does not appear to function as an agonist.

79516-82-8

C20H32O5

352.47

20-hydroxy Leukotriene B4;20-hydroxy Leukotriene B4

Ethanol:>50 mg/mL (per Rao Maddipati)
DMF:>50 mg/mL (per Rao Maddipati)
PBS (pH 7.2):>1 mg/mL (from 13(S)-HODE)
DMSO:>50 mg/mL (per Rao Maddipati)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years