GRK5-IN-4 (Compound 16d, CCG-265328) 是一种有效的选择性共价GRK5(G 蛋白偶联受体激酶 5) 抑制剂，其IC50为 1.1 μM。GRK5-IN-4 对 GRK5 的选择性是 GRK2 的90倍。GRK5-IN-4 可用于心力衰竭研究。

GRK5-IN-4 (Compound 16d, CCG-265328) is a potent and and selective covalent GRK5 (G protein-coupled receptor kinase 5) inhibitor, with an IC 50 of 1.1 μM. GRK5-IN-4 shows 90-fold selectivity over GRK2. GRK5-IN-4 can be used for heart failure research [1].

GRK5-IN-4 (Compound 16d) (0-4 h) displays a marked increase in apparent potency as a function of time [1].

2410794-89-5

C26H25N7O3

483.52

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years