MRGPRX1 agonist 4 (compound 1t) 是一种有效且具有口服活性的Mas 相关 G 蛋白偶联受体 X1 (MRGPRX1)正向变构调节剂，EC50为 0.1 μM。MRGPRX1 agonist 4 具有良好的代谢稳定性和口服生物利用度。在人源性 MRGPRX1 神经疼痛模型小鼠中，MRGPRX1 agonist 4 能降低行为性热过敏反应。MRGPRX1 agonist 4 可用于神经性疼痛的研究。

MRGPRX1 agonist 4 (compound 1t) is a potent and orally active Mas-related G protein-coupled receptor X1 (MRGPRX1) positive allosteric modulator with an EC 50 value of 0.1 μM. MRGPRX1 agonist 4 has good metabolic stability and oral bioavailability. MRGPRX1 agonist 4 can reduce behavioral heat hypersensitivity in a neuropathic pain model humanized MRGPRX1 mice. MRGPRX1 agonist 4 can be used for researching neuropathic pain [1].

C23H17Cl2F3N2O2S

513.36

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years