PTP1B-IN-18 是一种具有口服活性的完全混合型蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制剂，其Ki值为 35.2 μM。PTP1B-IN-18 可用于 2 型糖尿病的研究。
产品描述
PTP1B-IN-18 is an orally active complete mixed type protein tyrosine phosphatase 1B ( PTP1B ) inhibitor with a K i of 35.2 μM. PTP1B-IN-18 can be used for type 2 diabetes research [1].
体内活性
PTP1B-IN-18 (Compound 44; 100 mg/kg; p.o.; single administration) reduces 23% of the blood sugar level [1]. Animal Model: Female Wistar rats weighing 200-250 g (type 2 diabetic rat model) [1] Dosage: 100 mg/kg Administration: Oral administration; single administration Result: Showed hypoglycemic effect under physiological conditions.
分子式
C26H19N3O4S
分子量
469.51
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
