SR-318 是p38 MAPK的选择性抑制剂，对 p38α，p38β 和 p38α/β 的IC50分别为 5 nM，32 nM 和 6.11 μM。它有效抑制全血中TNF-α的释放，IC50为 283 nM。它显示出抗癌和抗炎活性。
产品描述
SR-318 potently inhibits the TNF-α release in whole blood (IC50 = 283 nM). SR-318 is a potent and highly selective inhibitor of p38 MAPK. The IC50 values are 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively.
体外活性
SR-318 presents a potent and selective type-II p38α/β inhibitor,It is used as a chemical probe for targeting this particular inactive state of these two p38 isoforms.
Cas No.
2413286-32-3
别名
SR-318
储存和溶解度
DMSO:125 mg/mL (271.99 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
