Hydroxystilbamidine是一种能够结合 DNA 和 RNA 的染料， 也被发现是细胞核糖核酸酶的强效抑制剂。

Hydroxystilbamidine, a dye capable of binding to both DNA and RNA, has been found to be a powerful inhibitor of cellular ribonucleases.

Hydroxystilbamidine permits the recovery of mRNA after polysome released with Nonidet P-40 (NP-40). Sucrose gradient analysis of detergent-lysed postnuclear supernates is used to analyze the size distribution of NP-40-released polysomes. The heparin gradient shows some polyribosomes, whereas the Hydroxystilbamidine gradient shows a remarkably large peak of very heavy polyribosomes. This peak is obtained reproducibly if Hydroxystilbamidine is present before the addition of NP-40[1].

Hydroxystilbamidine is an effective suppressor of the plaque-forming cell (PFC) response when given before sheep erythrocytes (SRBC) stimulation. Hydroxystilbamidine depresses the plaque response of the treated mice. Fewer PFC are observed in Hydroxystilbamidine-treated mice throughout the experiment, but the level of suppression decreases with time. By day 14, the number of PFC observed in both the Hydroxystilbamidine treated mice and the control group is essentially at the background level[2].

495-99-8

C16H16N4O

280.32

羟芪巴脒;Bis(8-hydroxyquinolinium) sulphate;2-Hydroxy-4,4'-diguanylstilbene;Oxistilbamidinum;(E)-hydroxystilbamidine;Hydroxystilbamidine

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years