Congo Red 是偶氮染料指示剂，在pH 3.0的环境下呈紫罗兰色，在pH5.0的环境下呈红色，常用于组织切片中淀粉样蛋白的测定。

Congo Red is an azo dye. It binding been used as a diagnostic test for the presence of amyloid in tissue sections.

Congo Red histochemical stain may serve as a simple tool to investigate if the aggregates in mutant cells have misfolded β-pleated sheet secondary structures[1]. Congo Red histochemical dye is able to bind specifically to crossed β-pleated sheet structures. Wild-type HSPB1 should maintain protein homeostasis by binding proteins in non-native conformations, thereby preventing substrate aggregation. The T139M mutant, however, fails in this function and results in an accumulation of misfolded proteins, which are targeted by Congo Red for intercalating between the β-pleated sheet structures.

573-58-0

C32H24N6NaO6S2

675.69

刚果红;Direct Red 28;Congo Red

DMSO:100 mg/mL (143.54 mM,Need ultrasonic
H2O:4.16 mg/mL (5.97 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years