Syk Inhibitor II dihydrochloride dihydrate 是一种有效的，高选择性和 ATP 竞争性Syk抑制剂，IC50为 41 nM。Syk Inhibitor II dihydrochloride dihydrate 抑制 RBL 细胞释放5-HT，IC50为 460 nM。Syk Inhibitor II dihydrochloride dihydrate 对其他激酶的作用较小，并具有抗过敏作用。

Syk Inhibitor II dihydrochloride dihydrate is a potent, high selective and ATP-competitive Syk inhibitor with an IC 50 of 41 nM. Syk Inhibitor II dihydrochloride dihydrate inhibits 5-HT release from RBL-cells with an IC 50 of 460 nM. Syk Inhibitor II dihydrochloride dihydrate shows less potent against other kinases and has anti-allergic effect [1].

Syk Inhibitor II (compound 9a) dihydrochloride dihydrate shows less potent against PKCε, PKCβ2, ZAP-70, Btk, and Itk with IC 50 values of 5.1 μM, 11 μM, 11.2 μM, 15.5 μM, and 22.6 μM, respectively [1].

Syk Inhibitor II (Compound 9a; 10-100 mg/kg) dihydrochloride dihydrate is subcutaneously administered to mice 30 min before antigen challenge. Syk Inhibitor II inhibits the anaphylaxis reaction dose-dependently with an ID 50 value of 13.2 mg/kg [1].

1965323-05-0

C14H21Cl2F3N6O3

449.26

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years