OBAA 是一种有效的磷脂酶 A2 (PLA2) 抑制剂(IC50= 70 nM)，并且在布氏锥虫中阻断 Melittin 诱导的 Ca2+流入(IC50= 0.4 μM)。
产品描述
OBAA is a potent inhibitor of phospholipase A2 (PLA2) with an IC 50 of 70 nM. OBAA blocks Melittin-induced Ca 2+ influx in Trypanosoma brucei with an IC 50 of 0.4 μM [1] [2] [3].
体外活性
OBAA (5.7 μM) induces apoptotic cell death of human umbilical vein endothelial cells (HUVEC). Nearly all of the cells had disintegrated into apoptotic bodies after 16h of treatment [1].
体内活性
The immunologically induced bronchospasm in guinea pigs is markedly and dose-dependently inhibited by OBAA (2.5-7 mg/kg i.v.) [3].
Cas No.
221632-26-4
分子式
C28H44O3
分子量
428.65
别名
OBAA
储存和溶解度
DMSO:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
