hA2A/hCA XII modulator 1 (compound 14) 是一种三唑并吡嗪，一种有效的 hA2A 腺苷受体 (hA2AAR) 拮抗剂，对 hA2AAR、hA1AR、hA3AR 的Ki分别为 6.4 nM、4.819 μM、>30 μM。hA2A/hCA XII modulator 1 是一种有效的人碳酸酐酶 XII (hCA XII) 抑制剂，对 hCA XII、hCA II、hCA IX 和 hCA I 的Ki分别为 6.2 nM、46 nM、466 nM、8.351 μM。hA2A/hCA XII modulator 1 具有用于癌症研究的潜力。

hA2A/hCA XII modulator 1 (compound 14), a triazolopirazine, is a potent hA 2A adenosine receptor (hA 2A AR) antagonist with K i s of 6.4 nM, 4.819 μM, >30 μM for hA 2A AR, hA 1 AR, hA 3 AR, respectively. hA2A/hCA XII modulator 1 is a potent human carbonic anhydrase XII (hCA XII) inhibitor with K i s of 6.2 nM, 46 nM, 466 nM, 8.351 μM for hCA XII, hCA II, hCA IX and hCA I, respectively. hA2A/hCA XII modulator 1 has the potential for cancer research [1].

2548963-55-7

C24H19N7O4S

501.52

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years