I-SAP is a high affinity TP receptor antagonist. At physiologic pH, I-SAP produces platelet shape change, but not aggregation, with an EC50 value of 9.7 nM. I-SAP binds to human platelets with the maximum binding obtained between pH 6.5 and pH 7.4. In washed human platelets, the Kd for I-SAP is 468 pM at pH 7.4 and 490 pM at pH 6.5.

133538-58-6

C22H30INO4S

531.45

I-SAP

DMSO:>25 mg/mL (from Pinane TXA2)
Ethanol:>100 mg/mL (from Pinane TXA2)
DMF:>50 mg/mL (from Pinane TXA2)
PBS (pH 7.2):>100 μ g/mL (from Pinane TXA2)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years