(R)-Hydroxychloroquine

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CAS NO:	137433-23-9
规格:	≥98%

Description: (R)-Hydroxychloroquine [(R)-HCQ] is the R-enantiomer of Hydroxychloroquine which is an antimalarial drug that inhibits Toll-like receptor 7/9 (TLR7/9) signaling, and shows efficiently against SARS-CoV-2.

References:

[1]. Cardoso CD, et al. Enantioselective analysis of the metabolites of hydroxychloroquine and application to an in vitro metabolic study. J Pharm Biomed Anal. 2005 Apr 1;37(4):703-8.

[2]. Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6.

[3]. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40.

[4]. Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Mar 9. pii: ciaa237.

纯度：≥98%

CAS：137433-23-9