MN58b 是一种选择性的胆碱激酶抑制剂，可抑制磷酸胆碱的合成。它通过诱导凋亡来减少细胞生长，具有抗肿瘤活性。
产品描述
MN58b is a selective inhibitor of choline kinase α (CHKα).
体外活性
MN58b (1-5 μM; 72 hours; SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells) has a marked effect on colony formation at 1 μM, and growth is completely abolished at 5 μM in all the cell lines[1]
体内活性
MN58b treatment significantly decreases phosphomonoesters in both HT29 and MDA-MB-231 xenografts. Phosphocholine levels are found to correlate with choline kinase activities[2].
Cas No.
203192-01-2
分子式
C32H40Br2N4
分子量
640.51
别名
MN58b
储存和溶解度
DMSO:10mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
