F-15599 是一种高度选择性的 G 蛋白偏向 5-HT1A 受体激动剂，Ki值为 3.4 nM。

F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist(Ki : 3.4 nM).

F-15599 exerted very potent (ID50 = 0.095 and 0.0059 mg/kg, respectively) anti-aggressive effects in male WTG rats. At 4.5-fold higher dose ranges, the anti-aggressive effects were accompanied by concomitant motor inactivity and/or reduction of social engagement. Pretreatment with WAY-100635 counteracted the behavioural effects of both agonists[1].

F-15599 agonists were acutely administered intraperitoneally in aggressive resident male WTG rats confronting an intruder[1].

635323-95-4

C19H21ClF2N4O

394.85

F-15599

DMSO:10mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years