Potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Recuces tumor expansion and lengthens survival time in a mouse xenograft model of glioblastoma.

1313027-43-8

C70H121N29O15S4

1737.15

MM 54

H2O:2 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years