Calhex 231 HCl is a CaSR inhibitor via negative allosteric modulation. Calhex 231 HCl blocks Ca2+-induced accumulation of [3H]inositol phosphate with an IC50 of 0.39 μM in HEK293 cells. Calhex 231 HCl has the highly potential for diabetic cardiomyopathy (DCM) treatment. References: [1]. Yuan H, et al. Calhex231 Alleviates High Glucose-Induced Myocardial Fibrosis via Inhibiting Itch-Ubiquitin Proteasome Pathway in Vitro. Biol Pharm Bull. 2019 Aug 1;42(8):1337-1344. [2]. Petrel C1, et al. Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca(2+)-sensing receptor. J Biol Chem. 2003 Dec 5;278(49):49487-94.

纯度：≥98%

CAS：2387505-78-2