AMG510（Sotorasib）外消旋物是AMG-510的外消旋体，AMG-510是一种有效的KRAS G12C共价抑制剂，具有潜在的抗肿瘤活性。AMG 510（2252403-56-6） can exist in either of two atropisomeric forms and one is more active than the other. It selectively forms an irreversible covalent bond to the sulfur atom in the cysteine residue that is present in the mutated form of KRAS, but not in the normal form.
| 中文别名 | AMG-510，AMG-510 racemate,2252403-56-6,AMG510,AMG 510 |
| 英文别名 | AMG-510 racemate,2252403-56-6,4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one |
| CAS号 | 2252403-56-6 |
| SMILES | O=C(C=C)N1C[C@H](C)N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C(C5=C(O)C=CC=C5F)=N4)=O)CC1.[Racemate] |
| Inchi | 1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1 |
| InchiKey | NXQKSXLFSAEQCZ-SFHVURJKSA-N |
| 分子式 Formula | C30H30F2N6O3 |
| 分子量 Molecular Weight | 560.59 |
| 性状 | 固体粉末,Power |
| 储藏条件 Storage conditions | -20℃ 3 years年 4℃ 2 years年 / In solvent溶液中:-80℃ 6 months月 -20℃ 1 month月 |
