sAJM-589 is a novel, potent small molecule Myc inhibitor that disrupts the Myc-Max leucine-zipper heterodimer with IC50 of 1.8 uM; preferentially inhibits transcription of MYC target genes in P493-6 cell; suppresses cellular proliferation in diverse MYC-dependent cancer cell lines, including P493-6, Ramos, HL-60 and KG1a (IC50=0.8-2 uM); reduces Myc protein levels in these cells, possibly by promoting ubiquitination and degradation of Myc protein.
| 中文别名 | sAJM589(cas:2089-82-9) |
| 英文别名 | sAJM589,2089-82-9 |
| CAS号 | 2089-82-9 |
| SMILES | OC1=CC2=NC3=CC=CC=C3N=C2C4=CC=CC=C41 |
| Inchi | InChI=1S/C16H10N2O/c19-15-9-14-16(11-6-2-1-5-10(11)15)18-13-8-4-3-7-12(13)17-14/h1-9,19H |
| InchiKey | WZBDRAAGHRCRKM-UHFFFAOYSA-N |
| 分子式 Formula | C16H10N2O |
| 分子量 Molecular Weight | 246.26 |
| 闪点 FP | 269.6±20.4 ℃ |
| 沸点 Boiling point | 522.2±15.0 ℃ at 760 mmHg |
| Polarizability极化度 | 30.9±0.5 10-24cm3 |
| 密度 Density | 1.4±0.1 g/cm3 |
| 蒸汽压 Vapor Pressure | 0.0±1.4 mmHg at 25℃ |
| 性状 | 固体粉末,Power |
| 储藏条件 Storage conditions | -20℃ 3 years年 4℃ 2 years年 / In solvent溶液中:-80℃ 6 months月 -20℃ 1 month月 |
