KP-457 (KP457) is a novel, potent and selective inhibitor of disintegrin and metalloproteinase 17 (ADAM17) with potential usefulness in Cardiovascular Disease. It has higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC50s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively.
理化性质和储存条件
Molecular Formula: C21H24N2O7S2;
Molecular Weight: 480.55;
Synonym: KP457; KP 457; KP-457
SMILES: CS(=O)(NCC1=CC=C(C(N(C=O)O)CS(=O)(C2=CC=C(OCC#CC)C=C2)=O)C=C1)=O
