5-(N,N)-Dimethylamiloride Hydrochloride (Hexamethylene amiloride), an amiloride derivative, is a Na(+)-H+ exchange inhibitor that decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively.

纯度：≥98%

CAS：1428-95-1