2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is an endogenous cGAMP molecule found in mammalian cells, it binds to STING with high affinity and is a potent inducer of interferon-β (IFNβ). contains two distinct phosphodiester linkages, one between 2′-OH of GMP and 5′-phosphate of AMP, and the other between 3′-OH of AMP and 5′-phosphate of GMP. 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm and binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ).

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